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Stevenage, UK, 22 October 2024 - Laverock Therapeutics, a gene-silencing company with a uniquely powerful technology for the development of programmable advanced therapies to tackle major diseases, today announces it is to present new data on its innovative gene-silencing platform at the European Society of Gene & Cell Therapy (ESGCT) Conference in Rome 22-25 October. Led by COO Tom Payne, Laverock’s team of scientists will be presenting three posters covering the Company’s technology platform and its application to CAR T cells and tumour microenvironment (TME) responsive macrophages for oncology. The data demonstrates the broad utility of the gene silencing technology for the development of differentiated therapeutic products. In contrast to other approaches, Laverock’s technology allows gene silencing that is programmable – linking silencing to cell identity or state; tunable – giving precise control of gene expression; stable – avoiding transient affects or epigenetic silencing; and specific – showing minimal loss or gain of function effects. It is also readily multiplexable, allowing targeting of multiple pathways in a single engineering step. Laverock’s product-focused posters demonstrate tunable, multiplex silencing of checkpoint pathways in primary T-cells, and use of phenotype-specific miRNA expression patterns to control macrophage function in response to TME cues. Tom Payne, COO of Laverock, said: “Over the last year we have generated a complete set of data in human cells demonstrating the unique features of our technology – namely its ability to silence genes in a programmable, tunable, stable and highly specific manner across a number of target genes and cell types. We believe this will enable the development of safer, targeted cell therapies by engineering human cells that exhibit gene silencing of the right genes, in the right cell, and at the right time.” Poster presentations: P: 0653. Klucnika, A et al Gene Editing induced Gene Silencing (GEiGS®) - A new technology to transform advanced therapies by programmable gene silencing. (Thursday 24.10.24 14:15 – 15:30). P: 0694. Houghton, B et al Programmable, multiplex CAR T cell engineered with Genome Editing induced Gene Silencing (GEiGs). (Thursday 24.10.24 18:00 – 19:30). P:0780. Menon, V et al Gene Editing induced Gene Silencing (GEiGS) technology to develop TME-responsive macrophages for solid tumour immunotherapy. (Thursday 24.10.24 18:00 – 19:30). ENDS For further information please contact: Laverock Therapeutics: E: contact@laverocktx.com Media Enquiries: Charles Consultants Sue Charles – Sue@charles-consultants.com +44 (0)7968 726585 Chris Gardner - Chris@CGComms.onmicrosoft.com +44 (0)7956 031077 About Laverock Therapeutics Laverock Therapeutics is a gene-silencing company with a uniquely powerful technology which harnesses the cell’s natural gene regulatory mechanisms to develop a new generation of programmable advanced therapies to tackle major diseases. Laverock’s truly innovative technology re-directs naturally occurring micro RNAs (miRNAs) to conditionally silence genes in a way which is programmable, tunable, stable and specific. This opens a path to more effective, safer and accessible advanced therapies. Laverock is applying its technology through its own pipeline – targeting oncology and genetic diseases – and through partnerships. Laverock has a highly experienced leadership team with proven track records in biotechnology, pharma and academia and an exceptionally strong Board. Laverock completed a £13.5m seed round in September 2023. Its high-calibre investors include Calculus Capital, Eli Lilly and Company, Mercia Ventures, Maven Capital Partners, Eos, UK Innovation & Science Seed Fund and Tekfen Ventures. For more information, please visit www.laverocktx.com and follow us on LinkedIn .

Programmable, tunable, stable and specific gene silencing has been demonstrated across multiple target genes and multiple cell types PoC achieved with concomitant silencing of more than one gene Industrialisation of platform processes delivering significant increase in throughput Strategic in-house focus on development of pipeline of programmable advanced therapies in oncology and genetic disease Potential additional application to multiple high impact therapeutic areas through partnering including, hypoimmunogenicity/type 1 diabetes, inflammatory diseases and fibrosis

Stevenage, UK, 5 September 2024 - Laverock Therapeutics, a gene-silencing company with a uniquely powerful technology for the development of programmable advanced therapies to tackle major diseases, today announces its conference attendance programme for the remainder of 2024. Forthcoming events include: ISCT Europe Regional Meeting , 4 – 6 September in Gothenburg - speaking Healthtech Innovation Day , 17 – 18 September in Paris - speaking, investor meetings Sachs Biotech in Europe Forum , 25 – 26 September in Basel - speaking, investor meetings and partnering Chardan Genetics Medicines Conference , 30 September – 1 October in New York - speaking, investor meetings and partnering ARM Meeting on the Mesa , 7 – 9 October in Phoenix, AZ – speaking, investor meetings and partnering TechBio UK 2024 , 16 October in London - panellist ESGCT Congress , 22 – 25 October in Rome - scientific presentations BioEurope , 4 – 6 November in Stockholm - investor meetings and partnering Cell 2024 , 6 – 8 November in London - speaking, session chair, panellist David Venables, CEO of Laverock, said: “We are excited to be showcasing recent advances in our technology at a number of key investor, scientific and partnering events. Over the course of 2024, Laverock has further validated its platform’s ability to silence genes in a programmable, tunable, stable and highly specific manner across multiple target genes and cell types. We have also broadened the platform’s potential by demonstrating the ability to silence more than one gene concomitantly. These developments further expand the range of potential applications for Laverock’s technology.” To arrange meetings with the Laverock leadership team at any of these events, please contact: contact@laverocktx.com ENDS For further information please contact: Laverock Therapeutics: E: contact@laverocktx.com Media Enquiries : Charles Consultants Sue Charles – Sue@charles-consultants.com +44 (0)7968 726585 Chris Gardner – Chris@CGComms.onmicrosoft.com +44 (0)7956 031077 About Laverock Therapeutics Laverock Therapeutics is a gene-silencing company with a uniquely powerful technology which harnesses the cell’s natural gene regulatory mechanisms to develop a new generation of programmable advanced therapies to tackle major diseases. Laverock’s truly innovative technology re-directs naturally-occurring micro RNAs (miRNAs) to conditionally silence genes in a way which is programmable, tunable, stable and specific. This opens a path to more effective, safer and accessible advanced therapies. Laverock is applying its technology through its own pipeline – targeting regenerative medicine and oncology – and through partnerships. Laverock has a highly experienced leadership team with proven track records in biotechnology, pharma and academia and an exceptionally strong Board. Laverock completed a £13.5m seed round in September 2023. Its high-calibre investors include Calculus Capital, Eli Lilly and Company, Mercia Ventures, Maven Capital Partners, Eos, UK Innovation & Science Seed Fund and Tekfen Ventures. For more information, please visit www.laverocktx.com and follow us on LinkedIn .

Stevenage, UK, 26 March 2024 - Laverock Therapeutics, a gene-silencing company with a uniquely powerful technology for the development of programmable advanced therapies to tackle major diseases, today announces the appointment of Ali Elsley as Finance Director.  Ali has extensive experience in the biotechnology and pharma sector working with both private and public companies. She joins from Acacia Pharma Group plc, an early commercial-stage listed pharma company, where she was Group Financial Controller and Company Secretary and focused on equity fundraising, M&A activity and all aspects of financial operations. Prior to this, she spent 10 years as an auditor with PwC LLP in Cambridge, with a focus on early-stage biotech and pharma companies, together with advisory IPO work. She is a fellow of the Institute of Chartered Accountants in England and Wales and holds a degree in Archaeology and Anthropology from the University of Cambridge. In addition to Ali’s appointment, Laverock has significantly grown its team to 24 people, representing growth of 50% over the past year, and expanded its R&D facilities in the Stevenage Bioscience Catalyst as it continues to build its capabilities following its £13.5m expanded seed round announced in September last year, the second highest seed investment by a UK company in 2023. David Venables, CEO of Laverock, said: “Ali has an exceptional track record working with innovative biotechnology and pharma companies. I very much look forward to working closely with her and the rest of our fast-growing team as we continue to apply our uniquely powerful gene-silencing technology to the development of a new generation of programmable advanced therapies to tackle major diseases.” Ali Elsley, FD of Laverock, said: “Laverock’s technology has the potential to create a step-change in advanced therapies and I have been hugely impressed with the pace of progress since joining the company. The management team and Board are exceptionally strong, and I believe we have a very solid foundation from which to deliver on the promise.” ENDS For further information please contact: Laverock Therapeutics: E: contact@laverocktx.com Media Enquiries : Charles Consultants Sue Charles – Sue@charles-consultants.com +44 (0)7968 726585 Chris Gardner – Chris@CGComms.onmicrosoft.com +44 (0)7956 031077 About Laverock Therapeutics Laverock Therapeutics is a gene-silencing company with a uniquely powerful technology which harnesses the cell’s natural gene regulatory mechanisms to develop a new generation of programmable advanced therapies to tackle major diseases. Laverock’s truly innovative technology re-directs naturally-occurring micro RNAs (miRNAs) to conditionally silence genes in a way which is programmable, tunable, stable and specific. This opens a path to more effective, safer and accessible advanced therapies. Laverock is applying its technology through its own pipeline – targeting regenerative medicine and oncology – and through partnerships. Laverock has a highly experienced leadership team with proven track records in biotechnology, pharma and academia and an exceptionally strong Board. Laverock completed a £13.5m seed round in September 2023. Its high-calibre investors include Calculus Capital, Eli Lilly and Company, Mercia Ventures, Maven Capital Partners, Eos, UK Innovation & Science Seed Fund and Tekfen Ventures. For more information, please visit www.laverocktx.com and follow us on LinkedIn .

Within cell and gene therapy, there is a growing reliance on innovation in genome editing technology. David McCall (Senior Editor, BioInsights), speaks to Vlad Seitan, (Chief Scientific Officer, Laverock Therapeutics) about enhancing advanced therapies through a novel approach that combines the power of gene editing with the RNA interference (RNAi) pathway.

Laverock Therapeutics secures £1m funding via the Innovate UK Investor Partnerships Future Economy programme, supported by UKI2S. 

Laverock Therapeutics will present a series of posters at the European Society of Gene & Cell Therapy (ESGCT) Annual Congress in Brussels on 24-27 th October. The posters will focus on the therapeutic applications of Gene Editing induced Gene Silencing (GEiGS®) technology, demonstrating the wide range of therapy areas that can benefit from its use. Tom Payne, COO, Vlad Seitan, CSO, Anna Klucnika, Scientist, Vishal Menon, Scientist, and Alina Letzel, Scientist, will all be attending the conference. GEiGS uses universal gene editing tools to minimally edit non-coding genes and redirect their silencing activity towards a new target gene. This enables the generation of products with improved efficacy, safety and accessibility by ensuring cell type- or condition-specific activity. Laverock is currently developing programmes in regenerative medicine and immuno-oncology, with a focus on Type I Diabetes and solid tumour responsive T-cell and macrophage based immune therapies. To find out more and discuss potential partnering opportunities, visit the Laverock posters at P516, P582 and P706. The posters will be presented on Wednesday 25 th October, 6:15pm-7:30pm and Thursday 26 th October, 7:30pm-8:30pm, so a member of the team will be on hand to discuss the technology, or you can arrange a meeting during the conference by contacting contact@laverocktx.com . The posters being presented by Laverock, include: P516 Session: Immunotherapy & CART cells Engineering programmable, TME-responsive macrophages for solid tumour immunotherapy using Gene Editing induced Gene Silencing (GEiGS) technology P582 Session: Metabolic diseases Next generation, allogeneic cell therapies for Type 1 Diabetes – utilising Gene Editing induced Gene Silencing (GEiGS) technology to address current challenges P706 Session: Gene editing Gene Editing induced Gene Silencing (GEiGS) – A new platform for programmable cell engineering Laverock is recruiting! Check out the active roles on the website – www.laverocktx.com or speak to one of the team to find out more. The ESGCT Annual Congress is designed to promote basic and clinical research in gene therapy, cell therapy and genetic vaccines. The event will facilitate the exchange of information and provide key stakeholders the opportunity to come together and discuss the latest progress in these areas.

Laverock Therapeutics’ CEO David Venables will present at the annual Cell & Gene Meeting on the Mesa to be held October 10-12 in Carlsbad, California and livestreamed globally. Tim Allsopp, CTO, will be joining David in partnering meetings with companies who would like to better understand how Gene Editing induced Gene Silencing (GEiGS®) technology can be used to improve on their current developing generation of advanced therapies. Laverock Therapeutics is developing the next generation of programmable advanced therapies though its novel RNAi platform. GEiGS utilises the universal gene editing tools to minimally edit non-coding genes and redirect their silencing activity in a stable, consistent, tunable and programmable manner. This facilitates the development of a new generation of products with improved efficacy, safety and accessibility. Laverock is working on programmes in regenerative medicine and immuno-oncology, with a focus on Type I Diabetes and solid tumour responsive T-cell and macrophage based immune therapies. Organised by the Alliance for Regenerative Medicine, the Cell & Gene Meeting on the Mesa is a three-day conference featuring more than 120 dedicated company presentations by leading public and private companies, highlighting technical and clinical achievements over the past 12 months in the areas of cell therapy, gene therapy, gene editing, tissue engineering, and broader regenerative medicine technologies, as well as over 100 panelists and featured speakers. The following are specific details regarding Laverock Therapeutics presentation at the conference: Event: 2023 Cell & Gene Meeting on the Mesa Date: 12 th October 2023 Time: 11am Location: Park Hyatt Aviara Resort, 7100 Aviara Resort Dr., Carlsbad, CA 92011 Virtual attendance is available which includes a livestream of Laverock’s presentation and the ability to view all conference sessions on-demand. Please visit https://meetingonthemesa.com for full information including registration.

Laverock Therapeutics , established in 2021 to commercialise the gene editing induced gene silencing (GEiGS ® ) platform for all human therapeutic applications, is pleased to announce that it has expanded its seed funding round to £13.5M. This investment was led by Calculus Capital with additional participation by Eli Lilly and Company, Mercia Ventures , Maven Capital Partners , Eos , UK Innovation & Science Seed Fund and Tekfen Ventures . The funding will enable further development of the GEiGS technology and progression of Laverock’s programmes in regenerative medicine and immuno-oncology, with a focus on Type I Diabetes and solid tumour responsive T-cell and macrophage based immune therapies, through to in vitro and in vivo validation. A key part of this next phase will be bringing on new members of the team and expanding lab facilities. David Venables, CEO of Laverock, commented: “GEiGS is already showing significant potential to transform the safety and efficacy of advanced therapies and we are excited that this new investment will allow us to progress towards pre-clinical candidate selection. We’re pleased to welcome such an experienced group of investors on board, bringing extensive sector expertise which will help us to grow as a company and accelerate the development of targeted, responsive treatments.” Elizabeth Klein, Investment Director at Calculus, said: “We are delighted to support Laverock and its exceptional management team, led by CEO David Venables, as the company embarks on its next phase of expansion, pioneering a new era of programmable advanced therapies. We backed David's previous venture, Synpromics, which delivered an exceptional return for Calculus investors in 2019. Laverock's ambitious plans hold tremendous potential for the healthcare sector, and we are excited to be part of the journey.” ENDS For further information please contact: Laverock Therapeutics: E: contact@laverocktx.com Sciad Communications: E: pressteam@sciad.com T: +44 (0)20 3405 7892 Notes to Editors About Laverock Therapeutics Laverock Therapeutics is developing a unique gene silencing platform for the creation of programmable advanced therapies. The company was established in 2021 to commercialise the gene editing induced gene silencing (GEiGS) technology for human therapeutic applications. GEiGS provides significant advantages over current approaches allowing generation of products with improved efficacy, safety and accessibility. About GEiGS ® GEiGS uses universal gene editing tools to minimally edit non-coding genes and redirect their silencing activity (RNAi) towards a new target gene. GEiGS is strongly differentiated from other gene silencing approaches through its core stable, tunable and programmable attributes, ensuring cell type- or condition-specific activity. For more information, please visit www.laverocktx.com and follow us on LinkedIn .